• Shilpa Sharma

Methicillin-resistant Staphylococcus aureus (MRSA) remains a major public health issue in the world and a therapeutic challenge to be addressed. Infection with MRSA is one of the most common causes of nosocomial infections and is generally associated with high morbidity, mortality, duration of stay and cost. The bacterium that produces MRSA, staphylococcus aureus, is present in the skin, in the nose, in the bloodstream or in the urine. It affects a large proportion of inpatients and can be transferred between individuals. Resistance to methicillin in S. aureus is mediated by PBP2a, a penicillin-binding protein with low affinity to beta-lactams, encoded by the mecA gene. mecA code penicillin -binding protien 2a(PBP2a), an enzyme that causes cross-linking of peptidoglycans in the bacterial wall.PBP2a has a low affinity for B-lactamines, resulting in resistance to the entire class of antibiotics. The primary risk factor for MRSA infection in hospitalized patients is a weakened immunity system.Those at greatest risk of infection include infants, the elderly, chronic patients, burn survivors, organ transplant recipient cancer patients receiving chemotherapy agents, steroid users, diabetic patients, intravenous drug users, and those with AIDS. Diagnosis and Prevention of MRSA colonization in patients are important tools to limit the spread of this organism.

Peznicillin,Vancomycin, Pathogens, mecA gene

"Investigation of Methicillin-resistant Staphylococcus aureus on Hospital Acquired Paitents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.e377-e384, November-2022, Available :http://www.jetir.org/papers/JETIR2211463.pdf

"Investigation of Methicillin-resistant Staphylococcus aureus on Hospital Acquired Paitents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppe377-e384, November-2022, Available at : http://www.jetir.org/papers/JETIR2211463.pdf