• boothapati. sudharani
• Dr.p.veeralakshmi
• s.bhargavi
• G.pavankumar

In the arena of solubility enhancement, several problems are encountered. A novel approach based on lipid drug delivery system has evolved, pharmacosomes. Pharmacosomes are novel vesicular drug delivery systems. They are potential alternative to conventional vesicles. Pharmacosomes are the amphiphilic phospholipids complexes of drugs bearing active hydrogen that bind to phospholipids. Similar to other vesicular systems pharmacosomes provide an efficient method for delivery of drug directly in a controlled manner to the site of infection, leading to reduction of drug toxicity with no adverse effects. They also reduces the cost of therapy by improving bioavailability of medication, especially in the case of poorly soluble drugs. This approach as a drug delivery system certainly promises a reliable, safe, selective and precise method of drug delivery. They may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure. They are termed as “pharmacosomes” due to the linking of a drug (pharmakon) to a carrier (soma). Pharmacosome may be defined as a complex of neutral molecule possessing both positive and negative charge, water-loving and fat-loving properties. This narrative review describes the fundamental aspects of pharmacosomes including composition, method of preparation, method of characterization and their therapeutic application. Pharmacosomes have been prepared for various non steroidal anti inflammatory drugs, proteins, cardiovascular and antineoplastic drugs.

Pharmacosomes, Phospholipid, Amphiphilic, Bioavalaibility

"A UPDATED REVIEW ON PHARMACOSOMES: A NOVEL STRATEGY FOR CONTROLLED DRUG DELIVERY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.f375-f385, November-2022, Available :http://www.jetir.org/papers/JETIR2211549.pdf

"A UPDATED REVIEW ON PHARMACOSOMES: A NOVEL STRATEGY FOR CONTROLLED DRUG DELIVERY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppf375-f385, November-2022, Available at : http://www.jetir.org/papers/JETIR2211549.pdf