• Mr. Jitendra N. Bhalavi
• Dr. Dinesh P. Kawade
• Mr. Vaibhav M. Mohare
• Mr. Prasad A. Taile
• Mrs. chetna R. Pardhi

Hypertension occurs when blood pressure gets elevated to 130-139 mmHg(systolic) and 80-89 mmHg(diastolic). The cause of hypertension is the generation of angiotensin II (octapeptide) from angiotensin I (decapeptide) by an angiotensin-converting enzyme (ACE). This angiotensin II is further converted into angiotensin III by an action of an aminopeptidase. This angiotensin III is 2-10 times less potent than angiotensin II which is produced by an action of an angiotensin-converting enzyme (ACE). So, for the treatment of hypertension, it is necessary to target the angiotensin-converting enzyme (ACE). 1.28 billion adults aged 30-79 years worldwide have hypertension. Chirata is a bitter glycoside obtained from the Swertia chirata. From the all phytochemicals of Swertia chirata we have investigated some bitter glycosides from them which have the potential of inhibition against angiotensin converting enzyme (PDB ID: 1J36). The Swertia chirata is generally used as a bitter tonic. It is used since a very early period as a febrifuge. It is also prescribed for dyspepsia. It is the remedy for scanty urine and is also used in epilepsy. In this in-silico molecular simulation, we have selected 6 phytochemicals. Among the 6 selected phytochemicals of Swertia chirata, mangiferin showed the highest binding affinity (-10 kcal/mol) and displayed perfect binding with the amino acids of an angiotensin-converting enzyme (ACE). This study shows the potential of inhibition of bitter glycosides from swertia chirata against Drosophila AnCE (PDB ID: 1J36) for the treatment of hypertension. These computational simulation studies support the hypothesis that the bitter glycosides of Swertia chirata might be helpful for the treatment of hypertension.

Hyperstension, Angiotensin Converting Enzyme, Chirata, Phytochemicals, Bitter Glycosides, Angiotensin II.

"In-Silico Approach of Interaction Studies of Swertia Chirata Phytochemicals with Angiotensin Converting enzyme for the Evaluation of Antihypertensive Activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 12, page no.b859-b865, December-2022, Available :http://www.jetir.org/papers/JETIR2212199.pdf

"In-Silico Approach of Interaction Studies of Swertia Chirata Phytochemicals with Angiotensin Converting enzyme for the Evaluation of Antihypertensive Activity", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 12, page no. ppb859-b865, December-2022, Available at : http://www.jetir.org/papers/JETIR2212199.pdf