• Shubam Sharma
• Kaushalya Bains,
• Raveena Devi
• Dr. Sakshi

A new medicine delivery method termed a target drug delivery system uses liposomes. Noveldrug delivery systems are a cutting-edge technology that solves the issues with traditional medication administration systems. Liposomes are self-assembling (phospho)lipid-based drug vesicles with a core aqueous compartment enclosed in a bilayer (uni-lamellar) or a concentric series of several bilayers (multi-lamellar).In the present investigation, we have tailored pantoprazole sodium-loaded eudragit S 100 coated proliposomes to control the release of drug and to improve the stability of pantoprazole sodium and GIT tract fluid.pantoprazole sodium was enclosed in proliposomes that were then coated with Eudragit S100 to resist denaturation by the severe circumstances of the stomach and to deliver the medication to the intestinal environment. proliposomes loaded with pantoprazole sodium and covered in eudragit S 100 showed minimal release. The percentage of drug release increases but depends on the buffer's ph when the buffer is changed after two hours. The greatest release of pantoprazole sodium from coated proliposomes, 93%, was recorded at ph 7 buffer medium, respectively up to 24 hours, while a percentage release of 23% was seen at ph 5–6 medium.

Lipids, Proliposomes, Pantoprazole, Lamellar

"PROLIPOSOMES-LOADED LIPOSOME TO IMPROVE PANTAPRAZOLE STABILITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 12, page no.d433-d450, December-2022, Available :http://www.jetir.org/papers/JETIR2212359.pdf

"PROLIPOSOMES-LOADED LIPOSOME TO IMPROVE PANTAPRAZOLE STABILITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 12, page no. ppd433-d450, December-2022, Available at : http://www.jetir.org/papers/JETIR2212359.pdf