• Khamkar Pratiksha Nanabhau
• Kodre Sayali Sandip
• Shelar Rutuja Ramdas

The Drug-drug interactions (DDIs), which have a prevalence of 20–40% in developed nations and are particularly common in the elderly due to polytherapy. Particularly, poly-therapy raises the bar for therapeutic control and, thus, the danger of clinically significant DDIs, which can both lead to the emergence of adverse drug responses and lower clinical efficacy. The two primary categories of DDIs are pharmacokinetic and pharmacodynamics. In this review, we searched articles published using the Reference lists. We described the mechanism of pharmacokinetic DDIs with a focus on their clinical implications.

Absorption, adverse drug reaction, distribution, drug-drug interactions, excretion, metabolism, poly-therapy.

"Pharmacokinetic drug-drug interaction and their implication in clinical management", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 12, page no.e521-e527, December-2022, Available :http://www.jetir.org/papers/JETIR2212472.pdf

"Pharmacokinetic drug-drug interaction and their implication in clinical management", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 12, page no. ppe521-e527, December-2022, Available at : http://www.jetir.org/papers/JETIR2212472.pdf