• Jude Chukwudi Chime
• Adaora Stella Ogbuagu
• John Ogbaji Igoli

Traditional healers in the eastern part of Nigeria use Dalbergia hancie to treat majorly inflammation. The efficacy of this plant for this use has not been experimentally proven. Three solvents of different polarities; n- hexane, ethylacetate and methanol were used to extract biomolecules by soxhlet extraction and phytochemical analysis were carried out on the crude extracts. The anti - inflammatory activity was carried out using the method described by Winter et al (1962) with little modification. The acute toxicity was conducted using the method described by Dietrich Lorke 1983. The phytochemical tests showed the presence of alkaloids, steroids, flavonoids tannins and saponin in n-hexane, ethyl acetate and methanol crude extracts. The results of anti-inflammatory activity showed that n- hexane extract gave a decreasing percentage inhibition of inflammation 30 % at 1 hr, 18.8 % at 2 hrs, 13.3 % at 3 hrs, 14.29 % at 4 hrs, 14.29 % at 5 hrs, ethylacetate produces increasing percentage inhibition as follows; 14.3 % at 1 hr, 31.3 % at 2 hrs, 33.33 % at 3 hrs, 42.86 % at 4 hrs, 50 % at 5 hrs and methanol extract possess increasing percentage inhibition properties over inflammation; 24.3 % at 1 hr, 40 % at 2 hrs, 36 % at 3 hrs, 45.7 % at 4 hrs and 60 % at 5 hrs. In the toxicity test, extracts from the leaf of Dalbergie hancie were administered to mice at different concentrations of 10 mg/kg, 100 mg/kg, 1000mg/kg, 2000 mg/kg, 3000 mg/kg, 4000 mg/kg and 5000 mg/kg. There were no sign of toxicity and no death was recorded on the mice. These results authenticated the use of Dalbergia hancie as a remedy for various inflammatory disorder by the traditional healers, and that it is safe to take extracts from the leaf of Dalbergia hancie .

Dalbergia hancie, phytochemical, anti - inflammation, toxicity

"In vivo Anti - inflammatory and toxicity studies on crude leaf extracts of Dalbergia hancie Benth", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 1, page no.a507-a512, January-2023, Available :http://www.jetir.org/papers/JETIR2301064.pdf

"In vivo Anti - inflammatory and toxicity studies on crude leaf extracts of Dalbergia hancie Benth", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 1, page no. ppa507-a512, January-2023, Available at : http://www.jetir.org/papers/JETIR2301064.pdf