• Dr. T.S. Shanmugarajan
• B. Rajkumar
• V. Sharvani Shastri
• S. Gowtham

The skin is essential for performing sensory and homeostasis functions, including protecting deeper tissues from the external environment and regenerating damaged tissues. However, the dermal system as a whole and the extracellular matrix, in particular, have limited capacity for regeneration, which makes the effects of trauma, ischemia, and degenerative disease devastating and often irreversible. Currently, there is no effective treatment for functional scarless recovery after a skin injury, as new therapeutic strategies for enhancing endogenous repair mechanisms of the dermal system have become ineffective. One of the most promising approaches to address these issues is associated with the use of hydrogels, the three-dimensional (3D) networks formed by hydrophilic polymers containing up to 90% (w/w) of water. The role of stem cells loaded hydrogels in general skin tissue system regeneration and skin tissue defect treatment, in particular, has been widely reviewed in our study. Due to their ideal immunomodulatory, biomimetic, biocompatible, and fibroblast proliferative characteristics, the stem cells loaded with hydrogel have demonstrated tremendous potential for regenerating skin tissue defects.

Hydrogel, Adipose Stem Cells, Mesenchymal Stem Cells, Skin, Alginate, Gelatin, Chitosan.

"Recent Developments in the Stem Cells Loaded Natural Polymeric Hydrogel Scaffolds for Skin Tissue Engineering Applications.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 1, page no.a557-a562, January-2023, Available :http://www.jetir.org/papers/JETIR2301073.pdf

"Recent Developments in the Stem Cells Loaded Natural Polymeric Hydrogel Scaffolds for Skin Tissue Engineering Applications.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 1, page no. ppa557-a562, January-2023, Available at : http://www.jetir.org/papers/JETIR2301073.pdf