• KRITI JAIN
• NIRMAL KUMAR GANGULY
• DEEPA MEHRA
• SURAJIT GANGULY
• SHYAM AGGARWAL

Exosomes are small endosomal derived membrane extracellular vesicles that contain cell specific cargos such as lipid, protein, DNA, RNA, miRNA, long non-coding RNA, and some other cell components that are released into surrounding body fluids upon the fusion of multivesicular bodies (MVB) and the plasma membrane. Exosomes are one of a kind cell-to-cell communication mechanism that might pave the way for target therapy. Brain tumour are a serious concern among both physicians and patients. Therefore, exosomes are a promising therapeutic target for the diagnosis, prognosis, and treatment of brain tumor. On the other way, brain tumor therapy with effective therapeutic components such as siRNAs, mRNAs, proteins, could be developed. This review aims to have a comprehensive appraisal on exosome biogenesis in brain tumors and then highlights the current knowledge of their role by special focusing on the latest ongoing therapeutic strategies on brain tumors. However, further research is needed to fully comprehend the potential involvement of the exosome in brain tumor therapy protocols.

Exosomes, Brain tumor, biomarkers, immunotherapy, solid tumors, predictive biomarkers

"COMPREHENSIVE OVERVIEW ON POTENTIAL ROLE OF EXOSOMES AS A THERAPEUTIC TARGET IN BRAIN TUMORS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 1, page no.d294-d313, January-2023, Available :http://www.jetir.org/papers/JETIR2301336.pdf

"COMPREHENSIVE OVERVIEW ON POTENTIAL ROLE OF EXOSOMES AS A THERAPEUTIC TARGET IN BRAIN TUMORS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 1, page no. ppd294-d313, January-2023, Available at : http://www.jetir.org/papers/JETIR2301336.pdf