• Gayatri R. Amrutkar
• Mr.Viraj V. Naravane
• Ms. Smita S. Aher
• Dr.Prashant R. Malpure
• Dr. R. S. Bachhav

Internal quality control (IQC) is an essential element of routine analysis to ensure that the uncertainty of results found during procedure validation is maintained over a long period of time. The primary method of IQC is to analyze the surrogate material along with the test materials in each run of the analysis, thus addressing the run-by-run accuracy (a subset of the "intermediate conditions") defined by VIM3. This "control material" must be as similar in composition as possible to the normal test materials, although there are always some differences. Results from the control material (control values) are plotted on a control chart and out-of-control results should be investigated and problems corrected. Considerable care is required in obtaining the correct parameter values for establishing statistical control limits, which can only be adequately estimated by routine use of the analytical procedure. In contrast, target control limits must be established on a fitness for purpose basis and are necessarily broader than statistical control limits. Another type of internal quality control can be performed by analyzing duplicate test portions of some actual test samples. This provides a realistic variance, but only relates to repeatability accuracy. Another complication of duplication is that the accuracy of results typically varies with analyte concentration.

Analysis quality control, Internal quality control, Quality management, Methodology Steps, Quantitative Analysis.

"A REVIEW ANALYTICAL QUALITY CONTROL AND METHODOLOGY IN INTERNAL QUALITY CONTROL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 1, page no.d377-d384, January-2023, Available :http://www.jetir.org/papers/JETIR2301345.pdf

"A REVIEW ANALYTICAL QUALITY CONTROL AND METHODOLOGY IN INTERNAL QUALITY CONTROL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 1, page no. ppd377-d384, January-2023, Available at : http://www.jetir.org/papers/JETIR2301345.pdf