• Ujami Sheikh
• Vinod Dhote
• Kanika Dhote

In this research work an attempt has been made to formulate the topical drug delivery system of Terbinafine HCl in the form of hydro gel. The gel was prepared for topical use so the bioavailability if drug is increased and prevent the loss of drug from first pass metabolism. Hydrogel is a Topical drug administration drug delivery system anywhere in the body of ophthalmic, rectal, vaginal and skin. Hydrogel based micro valves have a number of advantages over conventional micro valves, including relatively simple. Fabrication, no external power requirement no integrated electronics. Hydrogel having good oxygen permeability and superior biocompatibility, low protein adsorption and cell adhesion. Antifungal drug is widely used for the treatment of the fungal infection such as itching, redness, and fungal infection. Hydrogel show good homogeneity, drug content, Spredability and stability and has a wider prospect for Topical preparation. Terbinafine HCl is widely used antifungal agent mostly used to treat fungal infection. Pre-formulation studies were carried out using polymer like HPMC, CMC, Carbapol and Guar gum. The literature survey indicates that Carbapol and HPMC an excellent gelling agent during the formulation of Hydro gel preparation. As Carbapol and HPMC is chief, easily available and have a wide regulatory acceptance, it was chosen as a gelling agent in the present study.

Terbinafine HCL, Topical Drug Delivery System, Carbapol, Polymer

"Formulation and Evaluation of Topical Hydrogel of Terbinafine HCL for Effective Management of Dermatophyte.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 1, page no.f390-f423, January-2023, Available :http://www.jetir.org/papers/JETIR2301555.pdf

"Formulation and Evaluation of Topical Hydrogel of Terbinafine HCL for Effective Management of Dermatophyte.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 1, page no. ppf390-f423, January-2023, Available at : http://www.jetir.org/papers/JETIR2301555.pdf