UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 2
February-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2302293


Registration ID:
508722

Page Number

c714-c724

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Title

A Review: in-situ Gel Drug Delivery System

Abstract

Over the past decade gel-based systems have emerged as a new approach to drug delivery system, attracting the interest of the scientific community. In-situ gels are a type of hydrogel which are in a solution form and are undergoes gelation under varying physiological conditions. The formation of the gel depends on factors such as temperature fluctuations, pH changes, ion exposure and ultraviolet radiation, electrical sensitivity, a critical enzyme from which the drug is released continuously and in a controlled manner. They are designed to detoxify the drug with long-term drug availability and ongoing drug use. Controlled discharge pattern offers the benefit of reduced administration frequency, improving patient compliance. The dose of the drug can also be reduced and that is why the toxicity, compared to conventional treatment. In controlled drug delivery, the drug is administered for a long time with zero order kinetics, so the availability of plasma drugs can be obtained. Significant progress has been made in the formulation of novels containing natural and synthetic polymers. There are several uses and benefits of an in-situ gelling system in modern life. This review mainly focuses on introduction to in situ-gel, its advantages and disadvantages, its mechanism, various approaches of in-situ gel formation, mechanism of drug release from the system, Temperature advancements triggered the in- situ gel system, Improvement in the pH triggered the in –situ gel system, Research has been conducted in the area of in –situ gel for the administration of eye medication.

Key Words

applications, in-situ gel, novel drug delivery system, release.

Cite This Article

"A Review: in-situ Gel Drug Delivery System ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.c714-c724, February-2023, Available :http://www.jetir.org/papers/JETIR2302293.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A Review: in-situ Gel Drug Delivery System ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppc714-c724, February-2023, Available at : http://www.jetir.org/papers/JETIR2302293.pdf

Publication Details

Published Paper ID: JETIR2302293
Registration ID: 508722
Published In: Volume 10 | Issue 2 | Year February-2023
DOI (Digital Object Identifier):
Page No: c714-c724
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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