UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 2
February-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2302300


Registration ID:
506966

Page Number

c772-c783

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Title

Synthesis and evaluation of some novel [5-(4-substituted)-2, 3-dihydro-1,3,4-oxadiazol-2-yl] aryl oxadiazole derivatives and different biological activities in vitro

Abstract

A number of substituted aryl oxadiazoles are known for their biological importance like antibacterial, antifungal, anticancer, antioxidants and antiinflamatory activities. The present investigation is carried for the synthesis of certain substituted aryl oxadiazoles and carried out their biological activities. Nine new derivatives of aryl oxadiazoles (Scheme I) were synthesized during the course of research work. The title compound were synthesized from pyarazinoic acid hydrazide react with substituted aryl aldehyde to give Schiff base.A Schiffs base on treatment with aromatic acids in presence of phosphorus oxychloride gives aryl oxadiazoles. The newly synthesized compounds were characterized by, IR, 1H-NMR, and CHN analysis selected compounds screened for antimicrobial, antitubercular, anti-inflammatory and antioxidant activities in vitro. Few of them have exhibited promising activities.

Key Words

Schiffs bases, aryl oxadiazoles, antimicrobial screening. IR, 1H-NMR, CHN analysis

Cite This Article

"Synthesis and evaluation of some novel [5-(4-substituted)-2, 3-dihydro-1,3,4-oxadiazol-2-yl] aryl oxadiazole derivatives and different biological activities in vitro", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.c772-c783, February-2023, Available :http://www.jetir.org/papers/JETIR2302300.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Synthesis and evaluation of some novel [5-(4-substituted)-2, 3-dihydro-1,3,4-oxadiazol-2-yl] aryl oxadiazole derivatives and different biological activities in vitro", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppc772-c783, February-2023, Available at : http://www.jetir.org/papers/JETIR2302300.pdf

Publication Details

Published Paper ID: JETIR2302300
Registration ID: 506966
Published In: Volume 10 | Issue 2 | Year February-2023
DOI (Digital Object Identifier):
Page No: c772-c783
Country: bilaspur, chattisgarh, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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