UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 2
February-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2302310


Registration ID:
507895

Page Number

d103-d111

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Title

A Comprehensive Review on formulate and evaluate sustained release matrix tablets of rabeprazole sodium using hydrophilic polymer hydroxypropyl methylcellulose (HPMC) alone, of two different viscosity grades of Hydroxypropyl methylcellulose (HPMC K4M & HPMC K15M.).

Abstract

A sustained release product may be considered one in which a drug is initially made available to the body in an amount sufficient to cause the desired pharmacological response as rapidly as is consistent with the properties of the drug determining its intrinsic availability for absorption; and one which provides for maintenance of activity at the initial level for a desirable number of hours in excess of the activity resulting from the usual single dose of drug. Sustained release and controlled release will represent separate delivery processes; sustained release constitutes any dosage from that provides medication over an extended period of time. Controlled release however, denotes that, system is able to provide same actual therapeutic control, whether this is temporal nature, spatial nature, or both. In other words, the system attempts to control drug concentration in target tissue. This correctly suggests that there are sustained-release systems that cannot be considered as controlled release. With most of orally administered drugs targeting is not primary concern, and it is usually intended for drugs to permeate to the general circulation and perfuse to other body tissues (the obvious exception being medication intended for local gastrointestinal tissue treatment), for this reason, most systems employed are of the sustained-release variety. It is assumed that increasing concentration at the absorption site will increase the rate of absorption and, therefore, increase circulating blood levels, which in turn promotes greater concentrations of the drug at the site of action. If toxicity is not an issue, therapeutic levels can thus be extended. Theoretically and desirably a sustained release delivery device, should release the drug by a zero-order process which would result in a blood-level time profile similar to that after intravenous constant rate infusion.

Key Words

SUSTAINED RELEASE MATRIX TABLET , HPMC (HPMCK4M & HPMCK15M)

Cite This Article

"A Comprehensive Review on formulate and evaluate sustained release matrix tablets of rabeprazole sodium using hydrophilic polymer hydroxypropyl methylcellulose (HPMC) alone, of two different viscosity grades of Hydroxypropyl methylcellulose (HPMC K4M & HPMC K15M.). ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.d103-d111, February-2023, Available :http://www.jetir.org/papers/JETIR2302310.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A Comprehensive Review on formulate and evaluate sustained release matrix tablets of rabeprazole sodium using hydrophilic polymer hydroxypropyl methylcellulose (HPMC) alone, of two different viscosity grades of Hydroxypropyl methylcellulose (HPMC K4M & HPMC K15M.). ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppd103-d111, February-2023, Available at : http://www.jetir.org/papers/JETIR2302310.pdf

Publication Details

Published Paper ID: JETIR2302310
Registration ID: 507895
Published In: Volume 10 | Issue 2 | Year February-2023
DOI (Digital Object Identifier):
Page No: d103-d111
Country: -, -, India .
Area: Science & Technology
ISSN Number: 2349-5162
Publisher: IJ Publication


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