• SHUSHOVAN BANIK
• Barun Kumar Prabhat

Rosmarinic acid is a polyphenolic compound with numerous pharmacological actions anti-inflammatory, immunomodulatory, and neuroprotective, as well as having antioxidant and anticancer activities. This article reviews the anticancer effects and mechanisms of Rosmarinic acid action in cell lines, animal model systems as well as human trials. The article discusses the cytotoxic and antiproliferative effects of the said phytochemical in dose and duration dependent manner. Amazingly, Rosmarinic acid induced cell cycle arrest and induction of apoptosis by altered the expression of many apoptotic genes differently has been extensively study throughout the world. In various cancer cell lines, Rosmarinic acid has been found to arrest cells in the G0/G1 phase. The article also aimed to review animal model studies wherein animals with induced cancers treated with Rosmarinic acid showed significant lower tumour cell viability, proliferation and invasive abilities as compared with normal cells. In conclusion the review of literature showed that Rosmarinic acid exerted apparent inhibitory effect on cancer cells in cell line, animals and human studies along with stimulatory effect on such cells to undergo apoptosis. The review also aim to further undertake wet lab studies regarding mechanisms by which Rosmarinic acid exert the said effects on various cancer models.

Phytochemicals, Rosamarinic acid, oxidative damage, inflammation, apoptosis, cell cycle arrest

"ANTICANCER POTENTIAL OF ROSMARINIC ACID ON DIFFERENT CANCERS: A REVIEW ON ITS PLAUSIBLE THERAPEUTIC POTENTIAL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.d744-d749, February-2023, Available :http://www.jetir.org/papers/JETIR2302392.pdf

"ANTICANCER POTENTIAL OF ROSMARINIC ACID ON DIFFERENT CANCERS: A REVIEW ON ITS PLAUSIBLE THERAPEUTIC POTENTIAL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppd744-d749, February-2023, Available at : http://www.jetir.org/papers/JETIR2302392.pdf