• MADHU KUMAR H M
• Dr. SHANKARYYA M
• MADHURI H R
• VARUN H
• PRATIKSHA C C

Background: The objective of this work was to develop and evaluate controlled released reconstitutable suspensions of Ofloxacin loaded microspheres. Results: The resulting microspheres obtained from emulsion solvent diffusion method were with good % yield and mean particle size of microspheres ranged from 52.37±1.54μm to 72.45±1.44μm and the encapsulation efficiencies ranged from 83.53±1.42 to 95.25±2.04%. The encapsulation efficiency was also found to be dependent on amount of polymer used in the formulation. The FTIR and DSC spectra confirmed that Ofloxacin and the polymers used in the formulations have no interaction. The microspheres were porous, smooth, round, and somewhat aggregated, according to scanning electron microscopy. The sustaining impact of microspheres was shown to be dependent on the polymer concentration and amount of cross-linking agent utilised in the formulation, according to in-vitro dissolution investigations. The amount of xanthan gum in the suspension changed the volume of sedimentation and redispersibility. Conclusion: This study suggested that stable suspensions of Ofloxacin loaded microspheres could be formulated with 0.6 % W/V xanthan gum by the addition of 20% D-sorbitol.

Ofloxacin, microspheres, Suspension, Xanthan gum and D-sorbitol.

"OFLOXACIN LOADED MICROSPHERES RECONSTITUTABLE SUSTAINED RELEASE SUSPENSIONS: FORMULATION AND EVALUATION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.e750-e769, February-2023, Available :http://www.jetir.org/papers/JETIR2302489.pdf

"OFLOXACIN LOADED MICROSPHERES RECONSTITUTABLE SUSTAINED RELEASE SUSPENSIONS: FORMULATION AND EVALUATION", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppe750-e769, February-2023, Available at : http://www.jetir.org/papers/JETIR2302489.pdf