• Mr. Shashank Kumar
• Dr.Pankaj Arora
• Dr. Namita Arora

The current work was investigated to augment the solubility and dissolution of the anti-hypertensive drug reserpine. The current study comprised development and optimization the reserpine-polyethylene glycol solid dispersion containing fast dissolving film using QBD approach for the treatment of the hypertension. The reserpine solid dispersion was prepared using the PEG 20000 through carrier fusion method. In preliminary screening two parameters amount of the PEG 20000 and amount of reserpine was selected for the optimization. The central composite response surface design employed to suggest a total 13 trial formulations of the reserpine-poly ethylene glycol solid dispersion for the following independent variables: amount of PEG 20000 (80mg and 160mg) and reserpine amount (2mg and 6mg) were adjusted to three different levels. Dissolution of the reserpine from the solid dispersion at 20min and the percentage solubility of each batch were measured. The new optimized solid dispersion (DRPSD14), which served as a check point, was obtained using a numerical optimization technique based on desirability techniques. The amount of reserpine (X1) and PEG 20000 (X2) that were used in the formulation of the optimal solid dispersion were 3.66 mg and 124.88 mg, respectively, yielding theoretical values of 14.94% percent solubility and 96.88% percent dissolution at 20 minutes, respectively. DRPSD14 containing fast dissolving film was prepared employing solvent casting. Different parameters like amount of HPMC, amount of plasticizer and their type were investigated over the characterization parameters of the fast-dissolving film. Twelve different formulation was prepared and characterized. The surface pH of tailored formulation was discovered between 6.83 and 7.19, lies close to neutral pH, indicating non irritating sublingual mucosa and, thus, be more accepted by the patients. Percentage drug content of all manufactured formulations, which ranged from 91.082±1.540% to 98.977±0.253%, demonstrating the drug's uniform distribution within the polymer film. Formulation DRPSD14FDF11, which includes all formulations, contains the most reserpine (98.977±0.253%) of any of them. Reserpine-polyethylene glycol fast dissolving film formulations DRPSD14FDF11 in vitro dissolution studies showed quick dissolution up to or more than 90% within 6 minutes.

Reserpine, Poly ethylene glycol, Glycerol

"Formulation and Evaluation of Polyethylene Glycol Reserpine solid dispersion containing fast dissolving Film for the treatment of Hypertension", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 2, page no.f169-f184, February-2023, Available :http://www.jetir.org/papers/JETIR2302522.pdf

"Formulation and Evaluation of Polyethylene Glycol Reserpine solid dispersion containing fast dissolving Film for the treatment of Hypertension", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 2, page no. ppf169-f184, February-2023, Available at : http://www.jetir.org/papers/JETIR2302522.pdf