• Divya.S.Nair
• Gnana Jebaslin .G
• Savitha Mol G.M
• Dr. Jayachandran Nair
• Dr. Prasobh G.R

According to recent surveys, it is estimated that the global population has been found to be living with anxiety disorders and it is the most prevalent psychiatric disorder. The purpose of this study was to analyze the anti-anxiety action of Gallic acid (GA) by computational docking analysis studies(CDAS) and also to make a survey for bioactive compounds, like, alkaloids, flavonoids, phenols, terpenoids, tannins and saponins, and to determine the total phenol content in the ripe fruits of F. jangomas. For this, the natural phenolic compound GA isolated from Flacourtia jangomas (FJ) was used as a ligand for molecular interaction and it has found out that FJ contains 39.86 µg/mg of GA after following ethanolic extraction of dried ripe fruits FJ. The receptors for anxiety were obtained from PDB database (PDB ID: 2Z64, 4KBY, 5I6X). CDAS was performed for these three receptors using Pyrx, Pymol, Openbabel based on scoring functions. The GA showed more binding affinity with receptor 2Z64 and optimum binding affinity with receptors 4KBY, 5I6X. These results indicated that the phenolic compound GA could be one of the potential ligands to manage anxiety.

Flacourtia jangomas, secondary metabolites, anxiety, docking, gallic acid.

"In Silico Anti-Anxiety Effect And Phytochemical Evaluation Of Gallic Acid Present In Flacourtia jangomas", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 3, page no.f429-f439, March-2023, Available :http://www.jetir.org/papers/JETIR2303555.pdf

"In Silico Anti-Anxiety Effect And Phytochemical Evaluation Of Gallic Acid Present In Flacourtia jangomas", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 3, page no. ppf429-f439, March-2023, Available at : http://www.jetir.org/papers/JETIR2303555.pdf