• Ashwini Bhitade
• Dr. Nilesh Mahadeo Khutle
• Dr.Sushma Rahul Singh
• Ajith Pillai

The aim of the work is to enhance the solubility, dissolution rate and then the bioavailability of a poorly water soluble Lovastatin, by formulating it as self-micro emulsifying drug delivery system. Solubility of lovastatin in various oils was determined to select the oily phase. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oily phase. The SMEDDS formulation was optimized by Heating cooling cycles, Percent Transmittance, droplet size and zeta potential tests. The optimized L-SMEDDS formulation containing Lovastatin, Capryol PGMC, Cremophor RH 40 and Labrafil M 2125 was further evaluated for TEM analysis, Drug content and In-vitro drug release studies. L-SMEDDS was further converted into S-SMEDDS by Adsorption technique using Neusilin US 2 as adsorbing agent and the S-SMEDDS were evaluated for various flow properties and SEM analysis. The L-SMEDDS and S-SMEDDS showed enhanced in vitro dissolution profile as of Plain drug. Hence, the results from both L-SMEDDS and S-SMEDDS suggest the potential use of SMEDDS to improve the solubility and further the bioavailability of BCS Class II drug lovastatin.

Lovastatin, poor water solubility,SMEDDS, Neusilin US 2, Solid SMEDDS

"Development of Solid Self Micro-emulsifying Drug Delivery Systems of Lovastatin Using Neusilin US 2", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 3, page no.g594-g619, March-2023, Available :http://www.jetir.org/papers/JETIR2303688.pdf

"Development of Solid Self Micro-emulsifying Drug Delivery Systems of Lovastatin Using Neusilin US 2", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 3, page no. ppg594-g619, March-2023, Available at : http://www.jetir.org/papers/JETIR2303688.pdf