• Bhagyaraj R
• Dr Prasobh GR
• Dr Sree Lekshmi RS

A SYSTEMATIC REVIEW ON NSAID INDUCED STEVEN JOHNSON SYNDROME ABSTRACT Non-steroidal anti-inflammatory drugs (NSAIDs) are the medicines that are frequently prescribed and taken by people all over the world. NSAIDs are among the many medications that have the significant potential for causing TEN or SJS. Skin responses involving mucosal or skin membrane separation include SJS and TEN. Males were less impacted than females. Drugs, infections, and genetic factors (HLA-A and HLA-B) were the main causes of SJS or TEN (mycoplasma pneumonia and herpes simplex virus). It's unclear exactly how SJS or TEN cause disease. The majority of SJS or TEN cases involve people over the age of 40. The optimum course of treatment for people with SJS or TEN is currently not supported by enough evidence due to the rarity of these disorders. The majority of medications, including antibiotics, anticonvulsants, and NSAIDs, cause SJS or TEN. To diagnose SJS or TEN, diagnostic tests such skin prick tests, PCR tests, and serology tests were utilised. In addition to receiving the greatest supportive care, patients are also given numerous medications such immunomodulators (IVIG), cyclosporine, systemic corticosteroids, TNF inhibitors, and plasmapheresis.

Steven Johnson syndrome, tumour epidermal necrolysis, non steroidal anti inflammatory drugs, acetaminophen, adverse drug reactions.

"A SYSTEMATIC REVIEW ON NSAID INDUCED STEVEN JOHNSON SYNDROME", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 3, page no.h48-h54, March-2023, Available :http://www.jetir.org/papers/JETIR2303708.pdf

"A SYSTEMATIC REVIEW ON NSAID INDUCED STEVEN JOHNSON SYNDROME", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 3, page no. pph48-h54, March-2023, Available at : http://www.jetir.org/papers/JETIR2303708.pdf