• Mrs.Smital Suresh Kokate

The purpose of this research is to design proniosomal gel drug delivery system of Enrofloxacin for veterinary drug delivery system. This can be done by the use of vesicular drug delivery system. Encapsulation of a drug in the vesicular structure of the phospholipids plays role to prolong the existence of the drug in the systemic circulation and thus enhance penetration into target tissue and reduce toxicity. The potential of proniosomes as a transdermal drug delivery system of Enrofloxacin was investigated by encapsulating the drug in various formulations of proniosomal gel composed of various ratios of cholesterol, prepared by coacervation-phase separation method. The formulated systems were characterized in vitro for size, vesicle count, drug content; drug release .The method of proniosome loading resulted in an encapsulation yield of 70.00 % to 88.04 %. In-vitro studies showed prolonged release of entrapped Enrofloxacin. This study results in a promising prolonged delivery system for Enrofloxacin and has good stability characteristics.

Enrofloxacin, Proniosomes, Veterinary, Phospholipid, Transdermal

" FORMULATION AND EVALUATION OF ANTIMICROBIAL ENROFLOXACIN PRONIOSOMAL GEL FOR VETERINARY DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 3, page no.h462-h489, March-2023, Available :http://www.jetir.org/papers/JETIR2303765.pdf

" FORMULATION AND EVALUATION OF ANTIMICROBIAL ENROFLOXACIN PRONIOSOMAL GEL FOR VETERINARY DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 3, page no. pph462-h489, March-2023, Available at : http://www.jetir.org/papers/JETIR2303765.pdf