• MOHAN PAKALA
• Sandya Priya Parthasaradhi

Abstract: The present study has been conducted to identify the Histological variations in ethanolic extract of Annona squamosa leaves treated stz-induced dibetic albino rat kidney. The histopathological observations were made to elucidate the relationship between lipid peroxidation and tissue damage in diabetic condition. The pathological changes in kidney might be due to increased free radical production and elevated lipid peroxidation. Whereas, in Annona treated, Glibenclamid and Annona treated diabetic rats the tubules and glomeruli damages caused by diabetes were recovered. In conclusion, it revealed that one month treatment with selected dosage of Annona is beneficial in countering the alterations in antioxidant enzyme system, oxidative enzymes and lipid metabolic profiles in Wistar strain rats. The changes in markers of oxidative stress which include triglycerides, phospholipids MDA content and total cholesterol indicate efficient adaptative machinery of oxygen species that was operated in the renal tissue in detoxification of antioxidant system that are produced due to diabetes. The study concluded that Annona treatment in diabetic rats improved the metabolic efficiency as well as the health status.

IndexTerms: Diabetic, annona squamosa, histopathological.

"HISTOLOGICAL STUDIES ON ETHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES TREATED STZ-INDUCED DIBETIC ALBINO RAT KIDNEY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.k167-k172, April-2023, Available :http://www.jetir.org/papers/JETIR2304A24.pdf

"HISTOLOGICAL STUDIES ON ETHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES TREATED STZ-INDUCED DIBETIC ALBINO RAT KIDNEY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. ppk167-k172, April-2023, Available at : http://www.jetir.org/papers/JETIR2304A24.pdf