• Sakshi Saxena
• Archana Rautela
• Reetu Papola
• Praveen Kumar Ashok

The pharmaceutical industry has long been interested in creating combinations of two or more active ingredients (APIs) in a single dosage form (bilayer tablets).The pharmacokinetic profile is based on the rapid-acting method providing drug loading, while the release method increasing the drug concentration in the therapeutic window for a longer period of time. Bilayer tablets have a similar release pattern of a mixture of the same drug. Many pharmaceutical companies are developing bilayer tablets for combined drug use to increase efficacy and reduce the likelihood of drug-drug interactions. The bilayer tablet is designed for transient release and separation of two different products when two drugs are used together, but also for release tablets with an immediate release layer as the load and the second layer. For bilayer tablets, drug release can be unidirectional if the drug is in the non-adherent upper layer and dispersed throughout the oral cavity. The immediate release mechanism of the bilayer tablet acts as a carrier, while the sustained release mechanism maintains the plasma drug concentration for a long time. This article explains why a good bilayer tablet should be designed and manufactured by a custom tablet to avoid bilayer issues such as layer separation, insufficient stiffness and poor single layer weight control.

Bilayer tablet, pharmacokinetics, modified drug release, effective release.

"NOVEL APPROACH OF BILAYER TABLET: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 5, page no.j94-j98, May-2023, Available :http://www.jetir.org/papers/JETIR2305960.pdf

"NOVEL APPROACH OF BILAYER TABLET: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 5, page no. ppj94-j98, May-2023, Available at : http://www.jetir.org/papers/JETIR2305960.pdf