• Sakeriya Saad Daud
• Asma Arif
• Godar Moinuddin Mubarak
• Bhagat Mohsinabanu
• Chokiwala Aadil

Turmeric extract has a spasmolytic effect on chicken ileum, which means that it reduces muscle contractions. The spasmolytic effect of turmeric extract is mediated by several mechanisms, including inhibition of cholinergic receptors, inhibition of calcium influx through L-type calcium channels, and down-regulation of acetylcholine-triggered molecular signaling pathways. The research was conducted in vitro, which means that it was done in a laboratory setting using isolated chicken ileum tissue. The research was conducted using three different extracts of turmeric: ethanol, acetone, and water. The research was conducted using methods of stimulating the chicken ileum: acetylcholine, histamine, and BaCl2. Acetone extract from turmeric shows the best spasmolytic effects on acetylcholine-induced contraction, while water extract from turmeric shows the best spasmolytic effects on histamine-induced contraction. The spasmolytic effects of turmeric extract may be beneficial for the treatment of conditions such as irritable bowel syndrome, inflammatory bowel disease, and constipation. The research found that all three extracts of turmeric had a spasmolytic effect on chicken ileum, Acetone extract shows a maximum antagonist effect on chicken ileum as compared to the other extracts of turmeric. but the acetone extract was the most effective. However, more research is needed to confirm these findings and to determine the optimal dose and duration of turmeric extract therapy.

spasmolytic, acetylcholine, histamine,

"TO STUDY & COMPARE THE ANTISPASMODIC EFFECT OF DIFFERENT TURMERIC EXTRACTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 5, page no.l634-l644, May 2023, Available :http://www.jetir.org/papers/JETIR2305B87.pdf

"TO STUDY & COMPARE THE ANTISPASMODIC EFFECT OF DIFFERENT TURMERIC EXTRACTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 5, page no. ppl634-l644, May 2023, Available at : http://www.jetir.org/papers/JETIR2305B87.pdf