• Dr. Manju Singh

Inhibition of Acetylcholinesterase activity in freshwater fish Catla catla is demonstrated in the present study using AchE as substrate. The fish on acute exposure to 1/5, 1/3, and 2/3 concentrations of LC50 value of dimethoate and malathion showed an increased percentage of inhibition in acetylcholinesterase activity with the increase in dose. This suggests that organophosphates induce a decrease in cholinergic transmission and consequent accumulation of acetylcholine in the tissues, namely, the brain, gill, and liver. Thus, disrupting normal physiology, and behaviour and ultimately may cause the death of the fish. The highest inhibition in AchE activity was observed in the brain followed by the gill and liver. It has been revealed that dimethoate caused a high percentage of inhibition in enzyme activity as compared to malathion in all experimental tissues.

Dimethoate, Malathion, Catla catla, Acetylcholine, Acetylcholinesterase.

"Changes in Acetylcholine and associated Acetylcholinesterase activity induced by some organophosphates in a freshwater fish Catla catla (Hamilton).", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 5, page no.p170-p182, May-2023, Available :http://www.jetir.org/papers/JETIR2305G25.pdf

"Changes in Acetylcholine and associated Acetylcholinesterase activity induced by some organophosphates in a freshwater fish Catla catla (Hamilton).", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 5, page no. ppp170-p182, May-2023, Available at : http://www.jetir.org/papers/JETIR2305G25.pdf