• Yukti Narendra Patel
• Dr. Alisha Patel

Dapagliflozin Propanediol Monohydrate and Linagliptin are used in ratio (10:5) for treatment of patient suffering with Type – 2 Diabetes mellitus. The objective of work is to develop simple, economic, accurate, precise methods for simultaneous estimation of both drugs by using spectrophotometric. First order derivative methods were developed and validated for quantitative determination of Dapagliflozin Propanediol Monohydrate and Linagliptin in synthetic mixture. First order derivative method were developed and validated by using distilled water and scan between 200 – 400 nm. UV spectrophotometric method for DPM and LNG were found to be linear over range of 6 – 22 μg/ml and 3 – 11 μg/ml respectively for First order derivative. The regression coefficient (R2) was found to be 0.9982 and 0.9999 for DPM and LNG respectively.

Dapagliflozin Propanediol Monohydrate, Linagliptin, First order derivative, Method validation

"FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE AND LINAGLIPTIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 6, page no.j163-j171, June-2023, Available :http://www.jetir.org/papers/JETIR2306923.pdf

"FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE AND LINAGLIPTIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 6, page no. ppj163-j171, June-2023, Available at : http://www.jetir.org/papers/JETIR2306923.pdf