• P. Mallikharjuna Prasad

The convergence of nanotechnology and biosensing has given rise to nanochip-biosensors, highly miniaturized diagnostic platforms that integrate nanomaterials, microfluidics, and biorecognition elements. These devices enable the real-time, ultrasensitive detection of disease biomarkers at early stages, often before clinical symptoms manifest. This review explores the principles, design, and applications of nanochip-biosensors for early diagnosis in oncology, infectious diseases, cardiovascular disorders, and neurodegenerative conditions. We analyze recent technological advances in nanoelectronic chips, graphene-based biosensors, and lab-on-a-chip systems, highlighting their potential to revolutionize personalized and point-of-care (POC) diagnostics. Challenges including signal stability, reproducibility, clinical validation, and regulatory hurdles are discussed, alongside future prospects for AI-integrated, wearable, and portable nanochipbiosensing devices.

Nanochip; Biosensors; Early disease detection; Nanotechnology; Point-of-care diagnostics; Biomarkers; Lab-on-a-chip.

"APPLICATION OF NANOCHIP-BIOSNERSORS FOR ENABLING EARLY DISEASE DETECTION AND DIAGNOSIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 6, page no.l101-l105, June-2023, Available :http://www.jetir.org/papers/JETIR2306B13.pdf

"APPLICATION OF NANOCHIP-BIOSNERSORS FOR ENABLING EARLY DISEASE DETECTION AND DIAGNOSIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 6, page no. ppl101-l105, June-2023, Available at : http://www.jetir.org/papers/JETIR2306B13.pdf