• Vishnupriya B V
• Panchamy Nair K
• Shabin P,
• Kavitha K V,
• Aswathy S S, Prasobh G R

The present study aimed to evaluate the anti-inflammatory potential of ethanolic extracts of Flacourtia jangomas fruit using in silico and in vitro methods. In silico anti-inflammatory activity was studied using molecular docking method. In vitro anti-inflammatory activity of the ethanolic extract of Flacourtia jangomas was performed by using albumin denaturation inhibition assay, cyclooxygenase inhibition assay, lipoxygenase inhibition assay and cellular nitrite inhibitory assays. The preliminary phytochemical analysis indicated the presence of flavonoids, phenolic compounds, tannins, terpenoids, saponins. In docking studies, ligand molecule quercetin shows binding affinity with NLRC4 and P2X7 receptors respectively. The extract inhibits protein denaturation, cyclooxygenase, lipoxygenase and cellular nitrite. In this study, the results demonstrated that the ethanolic extract of Flacourtia jangomas fruit possess moderate anti-inflammatory activity.

Anti-inflammatory activity, Flacourtia jangomas, docking studies, in vitro studies

"IN SILICO AND IN VITRO ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC FRUIT EXTRACT OF FLACOURTIA JANGOMAS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.b210-b225, July-2023, Available :http://www.jetir.org/papers/JETIR2307129.pdf

"IN SILICO AND IN VITRO ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC FRUIT EXTRACT OF FLACOURTIA JANGOMAS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppb210-b225, July-2023, Available at : http://www.jetir.org/papers/JETIR2307129.pdf