• Riang Salbia Tambunan
• Makmur Sitepu
• Ichawanul Adenin
• Deri Edianto

The histopathological features of endometrial adenocarcinoma sometimes overlap with those of endocervical adenocarcinoma, making it difficult to distinguish between the two. Patterns of immunohistochemistry allow for a more accurate identification of the tissue origin, one of which is vimentin. The aim of this study is to determine the role of vimentin in differentiating the primary tumor location in patients with cervical adenocarcinoma and endometrial adenocarcinoma. This is an analytical observational study with a cross-sectional design conducted at Adam Malik General Hospital from November 2022. The study involved two groups consisting of cervical adenocarcinoma and endometrial adenocarcinoma in paraffin blocks. Immunohistochemical examination of vimentin was performed on each group. Our results showed a significant difference in the expression of vimentin between the group with endometrial adenocarcinoma and cervical adenocarcinoma (p < 0.001). The vimentin test has a sensitivity of 100%, specificity of 91%, positive predictive value of 92%, and negative predictive value of 100%. These findings indicate that vimentin can differentiate the tumor location in endometrial adenocarcinoma, but not in cervical adenocarcinoma.

Cervical adenocarcinoma, endometrial adenocarcinoma, vimentin

"The Role Of Vimentin In Differentiating Endometrial Adenocarcinoma And Cervical Adenocarcinoma", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.b450-b453, July-2023, Available :http://www.jetir.org/papers/JETIR2307157.pdf

"The Role Of Vimentin In Differentiating Endometrial Adenocarcinoma And Cervical Adenocarcinoma", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppb450-b453, July-2023, Available at : http://www.jetir.org/papers/JETIR2307157.pdf