• Muhammad Fariz Saleh
• Ichwanul Adenin
• Letta Sari Lintang
• Sarah Dina

Fibroids, benign tumors in the uterus, affect the expression of the HOXA10 gene and growth factors involved in implantation. Disruption of HOXA10 gene expression can lead to implantation failure and changes in endometrial function. This study aims to evaluate the gene expression of HOXA10 in endometrial tissue in patients with uterine fibroids. This study was conducted as an observational analytical case-control study at Adam Malik General Hospital and affiliated hospital from November to December 2022, involving 22 women in each group. Ultrasound examination was performed to classify the uterine fibroids. Endometrial tissue samples were collected to assess the expression of the HOXA10 gene using immunohistochemical staining method. This study found that in the abnormal uterine fibroid group, 55% of cases showed HOXA10 expression at level +1, and only 5% had expression at level +3. In submucosal and intramural uterine fibroids, the majority (76.48%) exhibited HOXA10 gene expression at level +1. Statistical analysis indicated a significant difference in the expression pattern of HOXA10 in uterine fibroids between the normal and abnormal uterine fibroid groups (p<0.05). Furthermore, a significant association was observed between uterine fibroid classification and the level of HOXA10 expression (p<0.05). These findings indicate a decrease in HOXA10 expression in uterine fibroids, particularly in the submucous and intramural types.

Hoxa10, endometrium, uterine fibroids

"Gene Expression Of Hoxa10 In Endometrial Tissue Of Uterine Fibroid Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.b686-b689, July-2023, Available :http://www.jetir.org/papers/JETIR2307187.pdf

"Gene Expression Of Hoxa10 In Endometrial Tissue Of Uterine Fibroid Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppb686-b689, July-2023, Available at : http://www.jetir.org/papers/JETIR2307187.pdf