• AKSHAT GARG
• Dr. Prabhakar Vishvakarma
• Mr. Suraj Mandal

In many areas of the world, helminthiasis, a parasite illness brought on by numerous species, is still a serious public health issue. The major method of therapy has been conventional anti helminths medication; nevertheless, the growth of drug resistance and unfavorable side effects necessitated the investigation of alternate therapeutic approaches. The purpose of this study is to look into the possibility of using Carica papaya seeds as a herbal jelly to treat helminthiasis. The common papaya plant, Carica, has long been utilized in folk medicine for its anthelmintic qualities. Alkaloids, flavonoids, phenolic compounds, and carpaine, among other bioactive compounds abundant in papaya seeds that have demonstrated potential antiparasitic effects in prior research. To improve their platability and convenience of administration, papaya seeds were processed into a jelly formulation for this investigation. Experiments conducted in vitro and in vivo are part of the research design. Using standardized laboratory procedures, the papaya seeds jelly's effectiveness against several helminthic species will be assessed during the in vitro phase. This evaluation will look at how the Jelly affects helminthic viability, motility, and egg hatching. The formulation with the highest efficacy will be chosen for additional in vivo investigations after the positive invitro evaluation. Papaya seed jelly will be administered to helminth-infected animal models in order to evaluate its therapeutic potential. To assess the effectiveness and safety of the therapy, variables like worm burden reduction, fecal egg count, and histological analyses will be examined. The results of this investigation should shed important light on the possible application of carica papaya seeds jelly as a substitute therapy for helminthiasis. If successful, this herbal Jelly might provide a sustainable, affordable, and accessible solution for the population impacted by helminthic infection, especially in regions with restricted access to sources. To clarify the underlying mechanism of action and improve the formulation for therapeutic usage, more study is necessary.

Carica papaya, helminthiasis, anthelmintic, herbal jelly, bioactive compounds, natural alternatives, parasitic infection, synthetic drugs, clinical efficacy, safety.

"EXPLORING CARICA PAPAYA SEEDS EXTRACT AS A HERBAL JELLY FOR HELMINTHIASIS TREATMENT: A COMPREHENSIVE ANALYSIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.c751-c777, July-2023, Available :http://www.jetir.org/papers/JETIR2307280.pdf

"EXPLORING CARICA PAPAYA SEEDS EXTRACT AS A HERBAL JELLY FOR HELMINTHIASIS TREATMENT: A COMPREHENSIVE ANALYSIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppc751-c777, July-2023, Available at : http://www.jetir.org/papers/JETIR2307280.pdf