• Pradnya Nalawade

One pot three component green synthesis of substituted dihydropyrimidinone and its sulphur Analogues have been reported using mild, simple commercially available organic acids. The reaction was carried out at room temperature without using any solvent by mixing equimolar amount of ethyl acetoacetate, aromatic substituted Benzaldehyde and Urea/Thiourea with catalytic amount of mild acids such as glycine, oxalic acid, maleic acid and vinegar. The kinetics of the reaction was studied by varying the concentration of the acids and substituents on benzaldehyde. It was found that concentration of the acids has significant effect on the kinetics of the reaction. Further there is noticeable effect different acids on duration of product formation mainly attributed to change in pKa of the respective acids. Maleic acid and oxalic acid were found to be excellent catalyst for solvent less synthesis of dihydropyrimidinones and its sulphur analogues using Biginelli reaction with more than 85% yield. Chloro-substituted benzaldehyde moiety gives excellent yield of dihydropyrimidinone with both urea and thiourea. This reaction protocol serves robust and eco-friendly pathway for synthesis of dihydropyrimidinone its sulphur Analogues.

dihydropyrimidinone, acid catalyst, green synthesis, sustainable

"Solvent Less Green Synthesis of Substituted Dihydropyrimidinones and their Sulfur Analogues Using Mild Organic Acids", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.c801-c805, July-2023, Available :http://www.jetir.org/papers/JETIR2307284.pdf

"Solvent Less Green Synthesis of Substituted Dihydropyrimidinones and their Sulfur Analogues Using Mild Organic Acids", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppc801-c805, July-2023, Available at : http://www.jetir.org/papers/JETIR2307284.pdf