• Sonavati
• Ankit Diwan
• Kuldeep Ganju

The objective of this current work was to synthesized some 2-(1H-benzo[d]imidazol-1-yl)acetamide derivatives and evaluating the antibacterial activity of the synthesized compounds in gram positive and gram negative bacteria. The synthesis was accomplished in two steps that included synthesis of acetate derivative of benzimazole and converting the acetate to acetamide by reaction with appropriate amine. The antibacterial activity of the synthesized compounds was determined using zone of inhibition method against gram positive (S. aureus, B. subtilis) and gram negative bacteria (E. coli). The results revealed that the antibacterial action of the synthesized compounds was dose dependent. The compounds were mild to moderately antibacterial. The presence of small substituents in the compounds was not favorable for antibacterial activity (2a, & 2b) whereas aromatic as well as heteroaromatic ring in the amine favored antibacterial action (2c, 2d & 2e). The substitution of one hydrogen of the amino group with aromatic ring favored antibacterial action against gram positive bacteria (2c). On the other hand the presence of two aromatic rings on the nitrogen led to poor activity against gram positive bacteria (2d) while the activity was optimum against gram negative bacteria. It was evident from the results that the incorporation of heteroromatic ring as part of the amine group was highly beneficial for activity against both gram positive as well as gram negative bacteria.

Benzimidazole, acetamide, antibacterial, disc diffusion, characterization

"SYNTHESIS AND EVALUATION OF 2-(1H-BENZO[D]IMIDAZOL-1-YL) ACETAMIDE DERIVATIVES FOR ANTIMICROBIAL ACTIVITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.d775-d780, July-2023, Available :http://www.jetir.org/papers/JETIR2307393.pdf

"SYNTHESIS AND EVALUATION OF 2-(1H-BENZO[D]IMIDAZOL-1-YL) ACETAMIDE DERIVATIVES FOR ANTIMICROBIAL ACTIVITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppd775-d780, July-2023, Available at : http://www.jetir.org/papers/JETIR2307393.pdf