• Manish
• Pro. Ganesh Patel
• Dr. Kuldeep Ganju

The objective of the present investigation was to synthesize and evaluate the anti-inflammatory potential of some newer 1,3,4-thiadiazole compounds. All the compounds exhibited peaks of N-N stretching (1015-1045 cm-1), C-S-C stretching (640-655 cm-1), aromatic C-H stretching (3026-3099 cm-1). The vibrations of O-H stretching (3300-3400 cm-1), C-O stretching (1670-1340 cm-1), and C-N stretching (1215-1260 cm-1) stretching were also found in the corresponding compounds. The 1HNMR spectra of the compounds presented peaks at 6.6-7.9 corresponding to aromatic CH and 8.1-8.2 corresponding to the imine hydrogen (N=CH) in all the compounds. Peak of OH was obtained at around 5.1 in 4a, 4d and 4e. The compounds were evaluated for in vitro anti-inflammatory potential using albumin denaturation and inhibition of proteinase action methods. All the compounds exhibited dose dependent inhibition of albumin denaturation. The highest inhibition of albumin denaturation and antiproteinase action was exhibited by 4d with 63.87% and 45.44% inhibition respectively.

Thiadiazole, anti-inflammatory, antiprotease, albumin denaturation, absorbance, synthesis

"Synthesis Of Some Novel 1,3,4-Thiadiazole Derivatives And Assessment Of Their Inhibitory Action On Albumin Denaturation And Proteinase Action", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.f592-f603, July-2023, Available :http://www.jetir.org/papers/JETIR2307575.pdf

"Synthesis Of Some Novel 1,3,4-Thiadiazole Derivatives And Assessment Of Their Inhibitory Action On Albumin Denaturation And Proteinase Action", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppf592-f603, July-2023, Available at : http://www.jetir.org/papers/JETIR2307575.pdf