• MAHADEV D. UDAYAGIRI

The novel Schiff base ligand 5-bromo-N'-(2-hydroxy-4-phenyldiazenyl)benzylidene)-3-phenyl-1H-indole-2-carbohydrazide and its Cu(II), Co(II), Ni(II) and Zn(II) complexes were prepared, characterized and studied their biological activity. Newly prepared compounds are characterized by elemental analysis and various physico-chemical techniques like FT-IR, 1H NMR, ESI-mass, UV-visible, TGA analysis, molar conductance and ESR spectral techniques. The elemental analysis data and spectral study indicate octahedral geometry for Cu(II), Co(II) and Ni(II) complexes and tetrahedral geometry for Zn(II) complex. All the compounds were screened for their antibacterial and antifungal activity by MIC method. Further, antioxidant activity was performed by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and DNA cleavage activity by Agarose Gel Electrophorosis (AGE) method. All the newly prepared compounds were tested for antioxidant activity, The Schiff base ligand (L), Cu(II) and Co(II) complexes showed good activity.

Schiff base, indole, 2-hydroxy-4-(phenyldiazenyl)benzaldehyde, Transition metal complexes, powder XRD, ESR, DNA cleavage, antimicrobial, antioxidant

" SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITIES OF NOVEL SCHIFF BASE 5-BROMO-N'-(2-HYDROXY-4-PHENYLDIAZENYL)BENZYLIDENE-3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE AND ITS METAL (II) COMPLEXES.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 7, page no.k1-k19, July-2023, Available :http://www.jetir.org/papers/JETIR2307A01.pdf

" SYNTHESIS, CHARACTERIZATION, BIOLOGICAL ACTIVITIES OF NOVEL SCHIFF BASE 5-BROMO-N'-(2-HYDROXY-4-PHENYLDIAZENYL)BENZYLIDENE-3-PHENYL-1H-INDOLE-2-CARBOHYDRAZIDE AND ITS METAL (II) COMPLEXES.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 7, page no. ppk1-k19, July-2023, Available at : http://www.jetir.org/papers/JETIR2307A01.pdf