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Published in:

Volume 10 Issue 8
August-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2308320


Registration ID:
523167

Page Number

d154-d157

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Title

SIGNIFICANCE OF SCREENING FOR THYROID ANTIBODIES IN HEALTH CHECK-UPS

Abstract

SIGNIFICANCE OF SCREENING FOR THYROID ANTIBODIES IN HEALTH CHECK-UPS Kalarani R1, A Safiullah 2, C. Gopal3, S. Subramaniyam4 1 Research Scholar, Regenix Super Speciality Laboratories, Chennai – 94, 2 Consultant BioChemist, Regenix Super Speciality Laboratories, Chennai – 94, 3 Member Secretary (Retd), Coastal Aquaculture Authority, Chennai – 91, 4 Head of the Department of Biochemistry, Regenix Super Speciality Laboratories, Chennai - 94 Abstract Thyroid dysfunction is a common health problem affecting millions of people all around the world. One of the prominent types of thyroid disorder is Autoimmune Thyroiditis, known by testing the levels of thyroid antibodies. Major Thyroid antibodies are anti-thyroid peroxidase (TPOAb), anti-thyroglobulin antibody (TgAb) and TSH receptor antibodies (TrAb). Presence of thyroid antibodies leads to Thyroid autoimmunity (TAI). However, TAI is often undiagnosed since they are asymptomatic for a long period. In the present study, we assessed the link between TAI and significance of screening for TAI. It is a cross-sectional study conducted in subjects over 18years of age.Subjects included were known hypothyroid patients and individuals randomly selected from the public. The blood samples for thyroid profile analysis were collected from overnight fasting individuals. Thyroid parameters tested using Electro Chemiluminescence were, Total Thyroxine (T4), Total Triiodothyronine (T3) along with TgAb and TPO Ab. and using Ultra sensitive chemiluminescence wasThyroid Stimulating Hormone (TSH). . The results were subject to ANOVA and Chi square test to compare the data and p-value. e Among the 21 hypothyroid individuals, 15 were diagnosed with TAI (71.4 %). All 15 who had TAI were on treatment for thyroid dysfunction (reported with altered thyroid profiles initially, now corrected with medication), thus proving, Anti TPO and Anti TG were found to be associated with thyroid dysfunction. Among 23 ATP individuals, 17 were diagnosed with TAI (73.9 %), posing the risk of hypothyroidism in the later stages of life.. Individuals who were already on treatment with hypothyroidism and ones with TAI had highly significantly increased antibody levels when compared to controls. and they were highly statistically significant. Significant relations between presence of thyroid antibodies and thyroid profile alterations were established in the study, proving that Anti TPO and Anti TG were found to be associated with thyroid dysfunction. The results suggest that screening of Thyroid antibodies should be done during the health checkups for healthy individuals to conclude for the diagnoses of TAI.

Key Words

Thyroid antibodies, Auto immune thyroiditis, TPO Ab, Tg Ab, Thyroid disorder

Cite This Article

"SIGNIFICANCE OF SCREENING FOR THYROID ANTIBODIES IN HEALTH CHECK-UPS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.d154-d157, August-2023, Available :http://www.jetir.org/papers/JETIR2308320.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"SIGNIFICANCE OF SCREENING FOR THYROID ANTIBODIES IN HEALTH CHECK-UPS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppd154-d157, August-2023, Available at : http://www.jetir.org/papers/JETIR2308320.pdf

Publication Details

Published Paper ID: JETIR2308320
Registration ID: 523167
Published In: Volume 10 | Issue 8 | Year August-2023
DOI (Digital Object Identifier):
Page No: d154-d157
Country: Chennai, Tamil Nadu, India .
Area: Science & Technology
ISSN Number: 2349-5162
Publisher: IJ Publication


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