• Dr. T. Mahesh Kumar
• M. Deepa Shree

Abstract: The aim of the present work was to improve the solubility of highly insoluble carvedilol drug by cocrystallization technique. The cocrystals prepared using coformers by solvent evaporation and anti-solvent methods were characterized for saturated solubility, melting point, X-ray diffraction (XRD) and microscopy. Drug with coformers compatibility was established using FT-IR spectroscopy. The results showed that carvedilol cocrystals which contains mannitol or benzoic acid were nine fold increases in solubility in compared to pure carvedilol drug. Also, all the cocrystals prepared were shown an increase in melting point. In XRD, emergence of a new peak position compared to the pure drug indicates the formation of a new crystalline phase and proven the presence of cocrystals. Microscopy image of pure carvedilol drug in compared with different cocrystals prepared using both the methods, there was a significant difference observed with the specific shape and size of the cocrystals. Cocrystalization of carvedilol with selected coformers enhances its solubility and hence, this approach can be used as an alternate method to conventional methods of solubility enhancement like particle size reduction, use of solubility enhancers, etc. Also, the developed cocrystal replaces the use of insoluble carvedilol as such in any of pharmaceutical dosage forms like tablets, capsules or other formulations.

coformer, solvent evaporation, crystalline, cocrystal, solubility

"COCRYSTALLIZATION OF INSOLUBLE CARVEDILOL DRUG BY SOLVENT EVAPORATION AND ANTISOLVENT TECHNIQUES TO ENHANCE IT’S SOLUBILITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.d238-d246, August-2023, Available :http://www.jetir.org/papers/JETIR2308331.pdf

"COCRYSTALLIZATION OF INSOLUBLE CARVEDILOL DRUG BY SOLVENT EVAPORATION AND ANTISOLVENT TECHNIQUES TO ENHANCE IT’S SOLUBILITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppd238-d246, August-2023, Available at : http://www.jetir.org/papers/JETIR2308331.pdf