• Dr. Raj Mohan Mishra

Visha means poison, visha chikitsa or Agadtantra include the treatment of disease caused by poisons and toxins, such as spoilt food, animal, reptile and insect bites, poisonous minerals, metals and unsuitable food combinations. It is equivalent to toxicology in modern medicine. Medicinal plants are considered the prime and integral part of Ayurvedic system of medicine. A single herb or a drug possesses multiple uses and actions which need to be scientifically re-validated so as to show the potential of the drugs explained by the Acharyas to the present modern world. More than 1700 pharmacological actions have been described in Ayurveda, among which the Krimighna karma is also one. It is synonymous with other activities like Krimisudana, Krimiprashamana and Krimihara. This can be correlated to the antimicrobial activity of the modern pharmacology like antibacterial, antifungal, antiviral etc. In most developing countries, malnutrition and unsanitary living system contribute to massive burden of infectious diseases. Microorganisms such as bacteria, viruses, fungi and parasites, are present everywhere in the soil, water, and atmosphere and on the body surfaces, and are responsible for a large number of infectious diseases in human beings. Despite improved living conditions, wide spread vaccination and availability of effective antibiotics, infectious diseases continue to take very high rank as a cause of death in the world, which is more than ten million persons each year. In present conditions, effective, complete and timely management of these microbes is a must. Antibiotics provide the main basis for the therapy of infections especially of bacterial originDue to the emergence of antibiotic resistant pathogens in hospitals and homes, plants are being looked upon as an excellent alternate to combat the future spread of multidrug resistant microorganisms. The history of the use of medicinal plants for their therapeutic purposes probably dates back to the origin of man. There has also been an increase on the reliance of the use of medicinal plants by the population in the industrialized societies as herbal remedies have become more popular in the treatment of minor ailments and also on account of the increasing costs of personal health maintenance. Plants may contain constituents that can be used to treat diseases such as infections, inflammatory conditions and cardiovascular diseases, but the scientific information on most of these medicinal plants in use are lackingTherefore as part of the efforts to promote the use of medicinal plants either as an alternative or an adjunct to conventional medicine, it is necessary for scientists to carry out investigations into herbal medicines. This will help bridge the gap between conventional and herbal medicines. Though the available antibacterial drugs have been tried in most of the conditions, their reoccurrence is common, thus making it necessitate the need of an alternative and effective therapy. The drug Jayapala (Croton tiglium Linn.), which is a organic irritant poison and available everywhere and is known to have Krimighna activity. Jayapala is one such medicinal plant which is available abundantly and is attributed with krimighna property according to Rasatarangini. In present time there is lack of scientific evidence about antibacterial efficacy of these drugs. In this study try to Evaluation of properties of Jayapala beeja churna for its krimighna property w.s.r. to antibacterial activity on S. aureus and E. coli - an in vitro study. The strain of bacterias namely Staphylococcus Aureus- gram +ve bacteria and E. coli gram-ve bacteria were selected for the study as representative microorganisms. In the present study Agar well diffusion /Cup plate method has been followed to detect the Antibacterial property of the drug.

Jaypala Beej Churna, S-Aureus and E-Coli.

"STUDY OF JAYPALA BEEJ CHURAN FOR IT’S KRIMIGHAN PROPERTY W.S.R TO ANTIBACTERIAL ACTIVITY ON S-AUREUS, AND E-COLI DEALS WITH DETAIL IN-VITRO ANTI BACTERIAL STUDY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.e374-e386, August-2023, Available :http://www.jetir.org/papers/JETIR2308445.pdf

"STUDY OF JAYPALA BEEJ CHURAN FOR IT’S KRIMIGHAN PROPERTY W.S.R TO ANTIBACTERIAL ACTIVITY ON S-AUREUS, AND E-COLI DEALS WITH DETAIL IN-VITRO ANTI BACTERIAL STUDY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppe374-e386, August-2023, Available at : http://www.jetir.org/papers/JETIR2308445.pdf