• Dr. Md. Younus Ali

Food allergy and intolerance have gained considerable attention. In food-allergic individuals, IgE is produced against naturally occurring food components, primarily glycoproteins that usually retain their allergenicity after heating and/or proteolysis. However the present study has conducted to review of literature about IgE Mediated Allergic Disorders. The study was documentary analysis type. Information and data were collected from secondary sources. Information and data were collected from books, research reports, online Pubmed journal books, journals, different annual reports, different government and non government websites and different websites. A literature review was conducted by using the Pubmed and Medline databases with the keywords: allergy, allergic disorders, IgE mediated allergic disorders. A hand search was also undertaken to relevant journals identified by the electronic search and additional articles identified from the reference list of the key articles. From the review it was found that the diagnosis and management of IgE mediated food allergy that is believed to be responsible for most immediate-type food-induced hypersensitivity reactionsare characterized clinically by a variety of signs and symptoms that occur within minutes or hours after consumption of the offending food. Reactions may be limited or more generalized with involvement of the skin, nose, eyes, and/or lungs. In more severe cases, cardiovascular symptoms including hypotension, shock, cardiac dysrhythmias and death can occur. Adults tend to be allergic to fish, crustaceans, peanuts and tree nuts but children tend to be allergic to cow’s milk, egg white, wheat and soy more frequently. “Emerging” food allergens include tropical fruits, sesame seeds, psyllium, spices and condiments. These allergies frequently represent a cross-allergy to an allergen derived from another source, e.g. pollens or natural rubber latex. The evaluation of IgE-mediated food allergy relies on a careful history, physical examination, appropriate skin testing or in vitro testing with food extracts, and/or double blind, placebo controlled food challenges. Avoidance remains the mainstay of therapy. However, allergens may be “hidden” and labeling can be non-precise or misleading, thereby severely hampering prevention. Patients with severe allergies should keep at hand an emergency kit with adrenaline, an antihistamine and an injectable rapid onset- of-action corticosteroid. At present there is no evidence to support the use of immunotherapy, except for research purposes. Production of “hypoallergenic” food is hampered by incomplete methods for assessing the allergenic potential of such novel foods.

Allergy, Immunoglobulin E (IgE), Allergic Disorders, Asthma, Bronchial asthma, Allergic rhinitis, Atopic dermatitis

"Study on IgE Mediated Allergic Disorders: A Literature Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.f80-f91, August-2023, Available :http://www.jetir.org/papers/JETIR2308512.pdf

"Study on IgE Mediated Allergic Disorders: A Literature Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppf80-f91, August-2023, Available at : http://www.jetir.org/papers/JETIR2308512.pdf