UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 8
August-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2308553


Registration ID:
523789

Page Number

f457-f468

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Title

FORMULATION AND EVALUATION OF BUDESONIDE ORODISPERSIBLE FILM FOR EOSINOPHILIC ESOPHAGITIS

Abstract

EOE is a long-term immune-mediated condition causing esophageal dysfunction and inflammation. Treatment options include proton pump inhibitors and swallowed topical steroids. This study aims to develop an orodispersible film containing budesonide, a poorly soluble anti-inflammatory medication, based on limited trials. The solvent casting technique is used to formulate orodispersible film. Preliminary batches were prepared for the selection of polymers, and from the preliminary batches, HPMC E15 LV combined with PEG 400 as a plasticizer demonstrated outstanding in vitro disintegration time and cumulative percent dissolution. A 32 factorial design with three levels and two factors was used, with polymer (X1) and plasticizer (X2) as independent variables. Formulated films were evaluated for their appearance, thickness, weight variation, surface pH, folding endurance, disintegration time, and in vitro dissolution rate. After evaluating the various batches of films, the F5 batch achieved the desired results, releasing 98.82% of the medication in just 5 minutes, resulting in quick film dissolution.

Key Words

Eosinophilic Esophagitis (EOE), Budesonide, HPMC E15, Solvent casting, Orodispersible film (ODF).

Cite This Article

"FORMULATION AND EVALUATION OF BUDESONIDE ORODISPERSIBLE FILM FOR EOSINOPHILIC ESOPHAGITIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.f457-f468, August-2023, Available :http://www.jetir.org/papers/JETIR2308553.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"FORMULATION AND EVALUATION OF BUDESONIDE ORODISPERSIBLE FILM FOR EOSINOPHILIC ESOPHAGITIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppf457-f468, August-2023, Available at : http://www.jetir.org/papers/JETIR2308553.pdf

Publication Details

Published Paper ID: JETIR2308553
Registration ID: 523789
Published In: Volume 10 | Issue 8 | Year August-2023
DOI (Digital Object Identifier):
Page No: f457-f468
Country: Pune, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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