• DR.M.RANGA PRIYA
• DR.R.MANIVANNAN
• M.ELAMPARUTHI
• C.ELAVARASAN

Abstract Adverse drug reactions (ADRs) continue to be a problem in modern medicine, especially in light of the complexity of therapies, the ageing of the population, and the rise in multimorbidity. Due to an increase in the number of new drug classes, studies have also revealed that admitted patients have a higher frequency of ADR. ADRs accounted for 6.2% of hospitalisations and 3.2% of ADRs during hospitalisation, per an Indian study. Sulphonylureas, thiazolidinediones, alpha-glucosidase inhibitors, and biguanides are diabetes medications that have significant ADR. Compared to patients receiving monotherapy, ADRs are manifested more frequently in patients receiving combo medication. Though there are no absolute contraindications to insulin therapy, the dose of insulin needs to be adjusted and monitored in numerous settings. The most common adverse drug reactions of metformin were lactic acidosis followed by hypoglycemia, hypersensitivity reactions, nausea, decreased appetite, vomiting, weakness, and diarrhoea. Thiazolidinediones have a few negative side effects, especially with prolonged use. Even while some ADRs are unanticipated, like anaphylaxis in a patient after a single uneventful exposure to a penicillin-containing drug, many may be avoided with enough planning and monitoring. However, reducing the likelihood of an ADR happening can be a significant method to lessen the risk of patient damage. Therefore, raising public awareness of the negative effects of anti-diabetic medications is necessary in the modern period. The Pharmacists play a vital role in monitoring ADR, educating the health care team and designing the medication chart. Thus, it is highly significant to frame a systematic protocol in ADR monitoring and managing them.

Index Terms: Adverse drug reactions, anti-diabetic medications, hypersensitivity, absolute contraindications, uneventful exposure, ADR monitoring

"ADVERSE DRUG REACTIONS OF ANTI-DIABETIC MEDICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.f573-f581, August-2023, Available :http://www.jetir.org/papers/JETIR2308567.pdf

"ADVERSE DRUG REACTIONS OF ANTI-DIABETIC MEDICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppf573-f581, August-2023, Available at : http://www.jetir.org/papers/JETIR2308567.pdf