• Vataparti Amardev Rajesh
• Dadala Mary Mamatha
• Matcha Bhaskar

In silico analysis facilitates in understand the mechanism and behavior of a protein in the living system using the computational simulation. Reports reveal that more than 300 insect pests contribute for a considerable damage to the agriculture industry result in great loss to the country’s economy. Among the damage caused by insect pests more than 25% of them are from the order lepidopterans. Extensive research on lepidopteran insects revealed that Juvenile Hormone Epoxide Hydrolase (JHEH) plays a key role in degenerative mechanism of Juvenile Hormone (JH), which is essential for Insect growth and reproduction. Because of the JHEH role in JH degenerative mechanism, in the present study the JHEH gene sequence is retrieved from sequence database and homologues lepidopterans were searched using Blastx for comparative analysis. Primary sequence analysis, secondary sequence analysis, functional domains and evolutionary relationship among the homologues sequence of Ha JHEH are studies using various bioinformatics tools to establish a base for insect pest biocontrol strategy using its own enzyme.

Comparative in silico sequence analysis, Helicoverpa armigera (Ha), Juvenile Hormone (JH), Juvenile Hormone Epoxide Hydrolase (JHEH), Lepidopteran insect pests biocontrol strategy

"Exploring Bio Control Strategies to Control Insect Pests by Comparative In Silico Analysis of Helicoverpa armigera Juvenile Hormone Epoxide Hydrolase Enzyme with Selected Homologues Lepidopteran Insects", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.g46-g53, August-2023, Available :http://www.jetir.org/papers/JETIR2308606.pdf

"Exploring Bio Control Strategies to Control Insect Pests by Comparative In Silico Analysis of Helicoverpa armigera Juvenile Hormone Epoxide Hydrolase Enzyme with Selected Homologues Lepidopteran Insects", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppg46-g53, August-2023, Available at : http://www.jetir.org/papers/JETIR2308606.pdf