• SIVADHARANI P
• JAYAPRADHA S R

A modular synthetic route that entails the synthesis of distinctive chalcones from aldehydes (Cinnamaldehyde and Furfuraldehyde) and acetophenone precursors in a manner consistent with Claisen-Schmidt condensation. On reaction with semicarbazide hydrochloride, certain substituted (E)-3-phenyl-5-styryl-4,5-dihydro-1H pyrazole-1-carboxamide and 5-(furan-yl)-3-phenyl-4,5-dihydro-1H-Pyrazole-1-carboxamide derivatives were synthesised from properly substituted chalcone. It is a simple, low cost and efficient method to produce 3,5 substituted (phenyl-styryl& phenyl-furan)-1H pyrazole carboxamide derivatives. It was confirmed by UV, FT-IR, XRD, 1H and 13C NMRs. The synthesized compounds possess antimicrobial activity, especially antibacterial activity.

3,5 substituted (phenyl-styryl& phenyl-furan) carboxamide derivatives, Claisen Schmidt condensation, Substituted chalcones from cinnamaldehyde and Furfuraldehyde, Recrystallization

"SYNTHESIS AND CHARACTERIZATION OF NOVEL (E)-3-PHENYL-5-STYRYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE AND 5-(FURAN-2-YL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE DERIVATIVES AND EVALUATION OF ITS ANTIMICROBIAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.g609-g615, August-2023, Available :http://www.jetir.org/papers/JETIR2308666.pdf

"SYNTHESIS AND CHARACTERIZATION OF NOVEL (E)-3-PHENYL-5-STYRYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE AND 5-(FURAN-2-YL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE DERIVATIVES AND EVALUATION OF ITS ANTIMICROBIAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppg609-g615, August-2023, Available at : http://www.jetir.org/papers/JETIR2308666.pdf