UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 8
August-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2308666


Registration ID:
524005

Page Number

g609-g615

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Title

SYNTHESIS AND CHARACTERIZATION OF NOVEL (E)-3-PHENYL-5-STYRYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE AND 5-(FURAN-2-YL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE DERIVATIVES AND EVALUATION OF ITS ANTIMICROBIAL ACTIVITIES

Abstract

A modular synthetic route that entails the synthesis of distinctive chalcones from aldehydes (Cinnamaldehyde and Furfuraldehyde) and acetophenone precursors in a manner consistent with Claisen-Schmidt condensation. On reaction with semicarbazide hydrochloride, certain substituted (E)-3-phenyl-5-styryl-4,5-dihydro-1H pyrazole-1-carboxamide and 5-(furan-yl)-3-phenyl-4,5-dihydro-1H-Pyrazole-1-carboxamide derivatives were synthesised from properly substituted chalcone. It is a simple, low cost and efficient method to produce 3,5 substituted (phenyl-styryl& phenyl-furan)-1H pyrazole carboxamide derivatives. It was confirmed by UV, FT-IR, XRD, 1H and 13C NMRs. The synthesized compounds possess antimicrobial activity, especially antibacterial activity.

Key Words

3,5 substituted (phenyl-styryl& phenyl-furan) carboxamide derivatives, Claisen Schmidt condensation, Substituted chalcones from cinnamaldehyde and Furfuraldehyde, Recrystallization

Cite This Article

"SYNTHESIS AND CHARACTERIZATION OF NOVEL (E)-3-PHENYL-5-STYRYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE AND 5-(FURAN-2-YL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE DERIVATIVES AND EVALUATION OF ITS ANTIMICROBIAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.g609-g615, August-2023, Available :http://www.jetir.org/papers/JETIR2308666.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"SYNTHESIS AND CHARACTERIZATION OF NOVEL (E)-3-PHENYL-5-STYRYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE AND 5-(FURAN-2-YL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE DERIVATIVES AND EVALUATION OF ITS ANTIMICROBIAL ACTIVITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppg609-g615, August-2023, Available at : http://www.jetir.org/papers/JETIR2308666.pdf

Publication Details

Published Paper ID: JETIR2308666
Registration ID: 524005
Published In: Volume 10 | Issue 8 | Year August-2023
DOI (Digital Object Identifier):
Page No: g609-g615
Country: DINDIGUL, TAMIL NADU, India .
Area: Chemistry
ISSN Number: 2349-5162
Publisher: IJ Publication


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