UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 8
August-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2308714


Registration ID:
524153

Page Number

h126-h146

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Title

DESIGN AND EVALUATION OF AN ANTIFUNGAL DRUG WITH CORTICOSTEROID LOADED MICROSPONGE HYDROGEL

Abstract

This study focuses on the development of a topical gel formulation using microsponges entrapping clotrimazole and Beclomethasone dipropionate to enhance treatment effectiveness. Clotrimazole is known for its antifungal, local anti-infective and growth-inhibiting properties while Ethyl cellulose serves as a glucocorticoid, corticosteroid and anti-inflammatory agent. The microsponges were prepared using the Quasi emulsion solvent diffusion method with ethyl cellulose as the polymer and PEG-200 as the plasticizer. The characterization of the microsponges involved assessing production yield, entrapment efficiency, viscosity, FTIR, particle size analysis and drug diffusion from the gel base. The microsponges appeared as free-flowing white powders with production yields ranging from 41% to 80%. A higher amount of polymer resulted in decreased drug content in the microsponges and the encapsulation efficiency varied from 41.3% to 73.8%. Scanning Electron Microscopy (SEM) revealed that the microsponges were porous but not uniformly spherical. The mean particle size ranged from 25.42μm to 53.43μm. FTIR and DSC studies demonstrated the compatibility of the drug and polymer during microsponge preparation. The drug release profiles of the microsponge gel formulations indicated a sustained drug release pattern when evaluated using pH 5.4 phthalate buffer. Among the formulations (F1 to F12) F6 showed promising sustained drug release of 91.92% for Clotrimazole and 90.35% for Beclomethasone dipropionate respectively. These findings suggest the potential of the developed gel formulation for improved topical drug delivery.

Key Words

Clotrimazole; Beclomethasone dipropionate; Ethyl cellulose; Microsponge; Quasi emulsion solvent diffusion method

Cite This Article

" DESIGN AND EVALUATION OF AN ANTIFUNGAL DRUG WITH CORTICOSTEROID LOADED MICROSPONGE HYDROGEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.h126-h146, August-2023, Available :http://www.jetir.org/papers/JETIR2308714.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

" DESIGN AND EVALUATION OF AN ANTIFUNGAL DRUG WITH CORTICOSTEROID LOADED MICROSPONGE HYDROGEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. pph126-h146, August-2023, Available at : http://www.jetir.org/papers/JETIR2308714.pdf

Publication Details

Published Paper ID: JETIR2308714
Registration ID: 524153
Published In: Volume 10 | Issue 8 | Year August-2023
DOI (Digital Object Identifier):
Page No: h126-h146
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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