• Pramod Kewat
• Dr. Yogita Tyagi
• Hiba Parveen
• Dr. Praveen Kumar Ashok

The formulation design discloses Vonoprazan fast-release tablets, to be used for treating various types of acid-related diseases. The tablet formulation uses various compatible excipients (like diluents, binders, disintegrants, glidants, and lubricants) by the wet granulation method. The fast-releasing tablet of Vonoprazan is rapid dissolution and absorption of the drug, bioavailability is high, may give rapid onset of action, and the intestinal residual is few, and hence few side effects. The bitter taste of Vonoprazan fumarate is masked with film-coating, this is expected to improve patient compliance. Vonoprazan fumarate does not require acid activation to bind to the proton pump. It is acid-stable and does not require an enteric coating to protect from acid degradation in the stomach. FTIR studies revealed that the drug was compatible with excipients, which were used in the formulation. In the present study film coated fast release tablet was developed because it is acid-stable and bitter taste. Accelerated stability study of selected optimized formulations was done as per ICH guidelines for 3 months at 40±2oC/ 75±5% RH, which revealed that formulations V1 & V8 have no significant change with respect to the initial characteristics observed.

Vonoprazan fumarate, Potassium Competitive Acid Blocker, acid-related disease, fast-release tablets, disintegrants, and wet granulation technique

"DESIGN AND ASSESSMENT OF FAST RELEASE TABLETS OF VONOPRAZAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.a373-a386, September-2023, Available :http://www.jetir.org/papers/JETIR2309045.pdf

"DESIGN AND ASSESSMENT OF FAST RELEASE TABLETS OF VONOPRAZAN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppa373-a386, September-2023, Available at : http://www.jetir.org/papers/JETIR2309045.pdf