• pratiksha verma

selective COX-2 inhibitor administered orally as analgesic and anti-inflammatory drug in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. The poor aqueous solubility of the drug leads to variable dissolution rates. The present work has been an attempt to prepare orodispersible tablets of celecoxib with a combination of superdisintegrants, amino acids, and sweeteners. Camphor was used as a sublimating agent. Tablets are prepared by direct compression and mannitol is used as bulking agent. The tablets were evaluated for weight variation, hardness, thickness, friability, disintegrating time, and drug release . Fast dissolving tablets are one of the FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. Some tablets are designed to dissolve fastly in saliva, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate.

Fast dissolving tablet, Celecoxib, Orodispersible tablet, Solid dispersion , formulation excipients .

"a review on use in the management of arthritis and acute pain of celecoxib", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.b260-b271, September-2023, Available :http://www.jetir.org/papers/JETIR2309129.pdf

"a review on use in the management of arthritis and acute pain of celecoxib", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppb260-b271, September-2023, Available at : http://www.jetir.org/papers/JETIR2309129.pdf