• Dr. Shakeeb Akhtar Nehal Ahmad
• Dr. Shahzad Ahmed Abdul Razzaque Ansari
• Mr. Pravin Trambak Netkar
• Mr. Mohammed Aatif Khan Rizwan Ahmed Khan
• Dr. Taarique Aftab Deshmukh

The aim of present work was formulation, development and characterization of metronidazole gastroretentive in-situ floating gel. The preliminary batches were formulated using sodium alginate, calcium carbonate, sodium citrate and distilled water. After preliminary preparation final formulations were prepared with different concentration of gelling agent (F1, F2, F3, and F4). The results shown that formula (F2) containing sodium alginate (1.5% w/v) and Xanthan gum (0.150% w/v) was the best formula regarding gelation time (5 seconds), floating duration (24 hours), pH (8.3), with drug release (99.80%) after 8 hrs, with the First Order release kinetic. It was concluded that the formulation of Metronidazole was gastroretentive floating in-situ gel, controls the release leading to improvement in drug absorption and bioavailability.

Key Words: Metronidazole, Sodium alginate, In-situ gel.

"FORMULATION, DEVELOPMENT AND CHARATERIZATION OF METRONIDAZOLE GASTRORETENTIVE IN-SITU FLOATING GEL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.b596-b602, September-2023, Available :http://www.jetir.org/papers/JETIR2309163.pdf

"FORMULATION, DEVELOPMENT AND CHARATERIZATION OF METRONIDAZOLE GASTRORETENTIVE IN-SITU FLOATING GEL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppb596-b602, September-2023, Available at : http://www.jetir.org/papers/JETIR2309163.pdf