• Pravin Kumar Singh
• Saravanan K
• Prabhas Nath Tripathi
• Omkar Singh

The practice of bioisosteres in drug discovery is a well-accepted designing concept that has illustrated utility as an approach to resolve a broad range of complications that may affect candidate optimization, development and robustness. In this article, the application of isosteric replacement is explored in a fashion that well defined on the development of practical solutions to problems that are experience in typical drug optimization and designing. The role of bioisosteres to affect inherent potency, selectivity, influence conformation and solve troubleshoots associated with drug feasibility, including P-glycoprotein recognition, modulating basicity, solubility, and lipophilicity and as well as to address issues associated with metabolism and toxicity are used as the underlying theme to capture a spectrum of creative applications of structural emulation in the designing of drug candidates. The imidazole scaffold represents important structural subunits for the discovery of new drug candidates. The demonstration that any molecule contains the imidazole core scaffold contains three carbon atoms, and two nitrogen with electronic-rich characteristics responsible for readily binding with a variety of enzymes, proteins, and receptors compared to the other heterocyclic rings, giving rise to a huge number of biologically active synthetic products, with a wider range therapeutic activities. Herein, we represent a thorough overview of the current research status of imidazole-based compounds with a wide variety of biological activities including anti-cancer, anti-microbial, anti-inflammatory, HMG-CoA reductase inhibitors and their potential mechanisms. This possesses a discourse binding pocket that is acknowledge by the imidazole scaffold in a common interrelated domain, describe the huge number of drugs contain imidazole substructure such as etomidate, eprosartan, metronidazole among many others.

Imidazole scaffold, HMG-CoA reductase, statin

"Synthesis, Characterization and Molecular docking of Statins rational Drug Design Approach", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.b603-b616, September-2023, Available :http://www.jetir.org/papers/JETIR2309164.pdf

"Synthesis, Characterization and Molecular docking of Statins rational Drug Design Approach", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppb603-b616, September-2023, Available at : http://www.jetir.org/papers/JETIR2309164.pdf