• Tukur Zayyanu
• Karnawat Monika

Curcumin, also known as turmeric, is a phytopolyphenol pigment derived from the Curcuma longa plant. the effects of curcumin have been well-known for over 4,000 years in eastern nations like China and India, Curcumin-rich diets have been shown to reduce inflammation and improve in the treatment of many human ailments, including diabetes and cancer, Alzheimer’s, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Methods 20ml of dimethyl sulfoxide were used to dissolve 100 mg of curcumin. 1 ml of this solution was added dropwise at a flow rate of 0.2 ml/min into boiling water (50 ml) under ultrasonic conditions with an ultrasonic power of 100 W and a frequency of 30 kHz. The ingredients were then room temperature combined for about 20 minutes after being sonicated for 10 minutes. A yellowish-orange powder was produced by freeze-drying the concentrated solution at 50⁰C at lower pressure. Objective: The objective of this study is to present an innovative nanobiotechnological method to enhance the curcumin bioavailability for antioxidant potency that will be used for an in vitro study in the treatment of age-related neurodegenerative diseases like Alzheimer's and Parkinson's using SH-SY-5Y neuroblastoma cells caused via inducers for these diseases, Conclusion: Curcumin is a naturally occurring functional polyphenol whose inadequate solubility and low bioavailability limit its applications, This research aims in enhancing curcumin bioavailability for achieving its antioxidant potency which will be use for in vitro studies targeting triggered neurodegeneration using SH-SY-5Y neuroblastoma cells.

Oxidative Stress, Neurodegenerative Diseases and Nanocurcumin

"CURCUMIN NANO ENCAPSULATION AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.e734-e745, September-2023, Available :http://www.jetir.org/papers/JETIR2309490.pdf

"CURCUMIN NANO ENCAPSULATION AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppe734-e745, September-2023, Available at : http://www.jetir.org/papers/JETIR2309490.pdf