• Mallamma T
• Pooja S

The method of solvent evaporation was chosen as it is a well-established technique for producing inhalable microparticles with controlled drug release properties. By using this method, we aimed to encapsulate Salbutamol Sulphate within biocompatible polymers, ensuring its stability and enhancing its therapeutic efficacy. S.S. microparticles are created by employing the biodegradable polymer PEG (poly ethylene glycol).The ability to effectively aerosolize different inhalable Salbutamol Sulphate formulations with appropriate (MMAD) mass median aerodynamic diameter 3.32& fraction of fine particles (FPF) ranging up to 62.40%. According to ICH requirements, stability tests on the improved formulations were conducted done with a relative humidity of 75% at a temperature of 40 °C. The % CDR at 12 hours was shown by the optimised batch F9 (85.32%). The optimised batch F9 had an average particle size of 3.06µm and kinetic models displays Fickian diffusion kinetics. The stability investigation on the improved batch F9, conducted in accordance with ICH criteria, revealed no appreciable change in the drug composition. These findings effectively showed that respirable microparticles made from salbutamol sulphate could be created, making them a promising delivery method for the quick and efficient treatment of COPD.

Salbutamol Sulphate, PEG, Meg, Solvent evaporation method.

"DESIGN AND DEVELOPMENT OF A MICROPARTICLE BASED INHALATION FORMULATION OF ANTIASTHMATIC DRUG BY QbD APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 9, page no.e800-e813, September-2023, Available :http://www.jetir.org/papers/JETIR2309498.pdf

"DESIGN AND DEVELOPMENT OF A MICROPARTICLE BASED INHALATION FORMULATION OF ANTIASTHMATIC DRUG BY QbD APPROACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 9, page no. ppe800-e813, September-2023, Available at : http://www.jetir.org/papers/JETIR2309498.pdf