• Reema Kushwaha
• Ankit Diwan
• Kuldeep Ganju

Oxadiazoles represent a class of heterocyclic compounds with multiple isomeric forms, including 1,2,4-oxadiazole, 1,3,4-oxadiazole, 1,2,5-oxadiazole, and 1,2,3-oxadiazole. These compounds consist of a five-membered ring containing two carbon atoms, two nitrogen atoms, and one oxygen atom. Among these isomers, 1,3,4-oxadiazole holds particular importance in medicinal chemistry. Synthesis: A systematic synthetic strategy was employed to access these derivatives, involving the careful selection of starting materials, reaction conditions, and purification techniques. The synthesis of these compounds was monitored and validated using a combination of thin-layer chromatography and various spectroscopic methods, including nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet-visible (UV-Vis) spectroscopy. Characterization of the synthesized compounds was further confirmed through mass spectrometry and elemental analysis. Antimicrobial Evaluation: The synthesized compounds were subjected to rigorous antimicrobial evaluation against a diverse panel of microorganisms, including clinically relevant bacterial and fungal strains. Minimum inhibitory concentration (MIC) assays were employed to determine the potency of these compounds in inhibiting microbial growth. Control experiments utilizing established antimicrobial agents provided valuable benchmarks for comparison. 1,2,3-Oxadiazole exhibits slight instability and can transform into a diazoketone tautomer. Various synthesis methods are available for 1,3,4-oxadiazole, with one common approach involving the cyclodehydration of acid and hydrazide derivatives using dehydrating agents such as phosphorus oxychloride (POCl3), trifluoroacetic anhydride, thionyl chloride, or polyphosphoric acid. 1,3,4-Oxadiazoles have been extensively investigated in medicinal chemistry due to their wide range of pharmacological activities, including anti-tubercular, analgesic, anti-inflammatory, antimicrobial, antimalarial, anti-oxidant, anticancer, antiviral properties, and more. This particular isomer is also a component of several commercially available medicinal agents used to treat various medical conditions.

Synthesis, Antimicrobial, 1,3,4-Oxadiazolyl Aniline Derivatives, Novel Compounds, Microorganisms, Minimum Inhibitory Concentration (MIC), Antibacterial, Antifungal, Structure-Activity Relationships (SAR), Drug Discovery

"SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 1,3,4-OXADIAZOLYL ANILINE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 10, page no.a436-a459, October-2023, Available :http://www.jetir.org/papers/JETIR2310050.pdf

"SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 1,3,4-OXADIAZOLYL ANILINE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 10, page no. ppa436-a459, October-2023, Available at : http://www.jetir.org/papers/JETIR2310050.pdf